Ki Summary

Reaction Details

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Target

Sigma non-opioid intracellular receptor 1

Ligand

BDBM50344435

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_748646 (CHEMBL1780499)

43±n/a nM

Citation

Rack, E; Fröhlich, R; Schepmann, D; Wünsch, B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem19:3141-51 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sigma non-opioid intracellular receptor 1

Name:

Sigma non-opioid intracellular receptor 1

Synonyms:

Type:

Protein

Mol. Mass.:

25307.17

Organism:

Cavia porcellus (Guinea pig)

Description:

Q60492

Residue:

223

Sequence:

MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP

BDBM50344435

n/a

Name

BDBM50344435

Synonyms:

CHEMBL1779999 | trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Type

Small organic molecule

Emp. Form.

C23H29NO2

Mol. Mass.

351.4819

SMILES

COC1Cc2ccccc2[C@@]2(CC[C@@H](CC2)N(C)Cc2ccccc2)O1 |r,wU:10.27,wD:13.17,(-1.47,-19.23,;-2.8,-20,;-2.81,-21.55,;-1.48,-22.32,;-1.48,-23.86,;-.17,-24.62,;-.17,-26.14,;-1.5,-26.91,;-2.81,-26.14,;-2.81,-24.62,;-4.14,-23.85,;-4.91,-25.2,;-6.63,-24.58,;-7.82,-25,;-7.05,-23.64,;-5.41,-24.27,;-7.83,-26.55,;-6.49,-27.32,;-9.17,-27.31,;-10.5,-26.53,;-10.49,-24.99,;-11.83,-24.21,;-13.17,-24.98,;-13.17,-26.53,;-11.84,-27.3,;-4.15,-22.31,)|

Structure