Reaction Details |
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Target | Synaptic vesicular amine transporter |
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Ligand | BDBM50344442 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747720 (CHEMBL1780875) |
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Ki | 137±n/a nM |
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Citation | Zheng, P; Lieberman, BP; Choi, SR; Plöessl, K; Kung, HF Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands. Bioorg Med Chem Lett21:3435-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter |
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Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
Type: | Protein |
Mol. Mass.: | 55689.58 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q01827 |
Residue: | 515 |
Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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BDBM50344442 |
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n/a |
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Name | BDBM50344442 |
Synonyms: | CHEMBL1780008 | rac-(2R)-3-(cyclohexylmethyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol |
Type | Small organic molecule |
Emp. Form. | C22H33NO3 |
Mol. Mass. | 359.5023 |
SMILES | COc1cc2CCN3CC(CC4CCCCC4)[C@H](O)CC3c2cc1OC |r| |
Structure |
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