| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasmepsin II |
|---|
| Ligand | BDBM50344447 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_747699 (CHEMBL1780854) |
|---|
| Ki | 2000±n/a nM |
|---|
| Citation |  McKay, PB; Peters, MB; Carta, G; Flood, CT; Dempsey, E; Bell, A; Berry, C; Lloyd, DG; Fayne, D Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design. Bioorg Med Chem Lett21:3335-41 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasmepsin II |
|---|
| Name: | Plasmepsin II |
|---|
| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51482.09 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | P46925 |
|---|
| Residue: | 453 |
|---|
| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
|
|
|
|---|
| BDBM50344447 |
|---|
| n/a |
|---|
| Name | BDBM50344447 |
|---|
| Synonyms: | CHEMBL1780016 | methyl-5-(diethylcarbamoyl)-4-methyl-2-(2-m-tolylquinoline-4-carboxamido)thiophene-3-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H29N3O4S |
|---|
| Mol. Mass. | 515.623 |
|---|
| SMILES | CCN(CC)C(=O)c1sc(NC(=O)c2cc(nc3ccccc23)-c2cccc(C)c2)c(C(=O)OC)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
