Reaction Details |
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Target | RAF proto-oncogene serine/threonine-protein kinase |
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Ligand | BDBM50344526 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747956 (CHEMBL1781333) |
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IC50 | 4±n/a nM |
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Citation | Ramurthy, S; Aikawa, M; Amiri, P; Costales, A; Hashash, A; Jansen, JM; Lin, S; Ma, S; Renhowe, PA; Shafer, CM; Subramanian, S; Sung, L; Verhagen, J Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors. Bioorg Med Chem Lett21:3286-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAF proto-oncogene serine/threonine-protein kinase |
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Name: | RAF proto-oncogene serine/threonine-protein kinase |
Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 73082.52 |
Organism: | Homo sapiens (Human) |
Description: | P04049 |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM50344526 |
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n/a |
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Name | BDBM50344526 |
Synonyms: | CHEMBL1778409 | N-methyl-4-(2-(4-(trifluoromethoxy)phenylamino)benzo[d]thiazol-5-yloxy)picolinamide |
Type | Small organic molecule |
Emp. Form. | C21H15F3N4O3S |
Mol. Mass. | 460.429 |
SMILES | CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1 |
Structure |
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