| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
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| Ligand | BDBM50344541 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_747956 (CHEMBL1781333) |
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| IC50 | 1±n/a nM |
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| Citation |  Ramurthy, S; Aikawa, M; Amiri, P; Costales, A; Hashash, A; Jansen, JM; Lin, S; Ma, S; Renhowe, PA; Shafer, CM; Subramanian, S; Sung, L; Verhagen, J Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors. Bioorg Med Chem Lett21:3286-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase |
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| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 73082.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM50344541 |
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| n/a |
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| Name | BDBM50344541 |
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| Synonyms: | 4-(2-(4-ethylphenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide | CHEMBL1778394 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N4O3 |
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| Mol. Mass. | 388.4192 |
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| SMILES | CCc1ccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NC)ccc3o2)cc1 |
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| Structure | 
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