Reaction Details |
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Target | Sphingosine 1-phosphate receptor 2 |
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Ligand | BDBM50344792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_749242 (CHEMBL1781185) |
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IC50 | 2800±n/a nM |
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Citation | Guerrero, M; Urbano, M; Velaparthi, S; Zhao, J; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett21:3632-6 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 2 |
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Name: | Sphingosine 1-phosphate receptor 2 |
Synonyms: | EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 38883.16 |
Organism: | Homo sapiens (Human) |
Description: | Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay. |
Residue: | 353 |
Sequence: | MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
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BDBM50344792 |
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n/a |
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Name | BDBM50344792 |
Synonyms: | 5-(2,5-dichlorophenyl)-N-(4-hydroxy-2,6-dimethylphenyl)furan-2-carboxamide | CHEMBL1779895 |
Type | Small organic molecule |
Emp. Form. | C19H15Cl2NO3 |
Mol. Mass. | 376.233 |
SMILES | Cc1cc(O)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl |
Structure |
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