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TargetSphingosine 1-phosphate receptor 5
LigandBDBM62407
Substrate/Competitorn/a
Meas. Tech.ChEMBL_749246 (CHEMBL1781189)
IC50 14000±n/a nM
Citation Guerrero, MUrbano, MVelaparthi, SZhao, JSchaeffer, MTBrown, SRosen, HRoberts, E Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett21:3632-6 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 5
Name:Sphingosine 1-phosphate receptor 5
Synonyms:EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41796.42
Organism:Homo sapiens (Human)
Description:n/a
Residue:398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
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  Blast E-value cutoff:
BDBM62407
n/a
NameBDBM62407
Synonyms:5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)-2-furamide | 5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamide | 5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide | 5-[2,5-bis(chloranyl)phenyl]-N-(2,6-dimethylphenyl)furan-2-carboxamide | SR-02000000251 | SR-02000000251-1 | cid_4492589
TypeSmall organic molecule
Emp. Form.C19H15Cl2NO2
Mol. Mass.360.234
SMILESCc1cccc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
Structure
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