| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50344929 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_748931 (CHEMBL1781379) |
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| IC50 | 41±n/a nM |
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| Citation |  Matasi, JJ; Brumfield, S; Tulshian, D; Czarnecki, M; Greenlee, W; Garlisi, CG; Qiu, H; Devito, K; Chen, SC; Sun, Y; Bertorelli, R; Geiss, W; Le, VD; Martin, GS; Vellekoop, SA; Haber, J; Allard, ML Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1. Bioorg Med Chem Lett21:3805-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50344929 |
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| n/a |
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| Name | BDBM50344929 |
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| Synonyms: | (R)-7-tert-butyl-1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophenyl)-7,8-dihydro-1H-imidazo[2,1-b]purin-4(5H)-one | CHEMBL1777935 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F3N5O |
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| Mol. Mass. | 481.5127 |
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| SMILES | CCN1C2=N[C@@H](CN2c2c(nc(-c3ccc(F)cc3)n2Cc2ccc(F)c(F)c2)C1=O)C(C)(C)C |r,t:3| |
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| Structure | 
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