Reaction Details |
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Target | Squalene synthase |
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Ligand | BDBM50344971 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_749032 (CHEMBL1781817) |
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IC50 | 131±n/a nM |
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Citation | Griebenow, N; Buchmueller, A; Kolkhof, P; Schamberger, J; Bischoff, H Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors. Bioorg Med Chem Lett21:3648-53 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Squalene synthase |
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Name: | Squalene synthase |
Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
Type: | PROTEIN |
Mol. Mass.: | 48114.76 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1352847 |
Residue: | 417 |
Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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BDBM50344971 |
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n/a |
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Name | BDBM50344971 |
Synonyms: | (1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxy-phenyl)-1-isopropyl-4H,6H-2,5-dioxa-3-aza-benzo[e]azulen-4-yl]-acetyl}-piperidin-4-yl)-acetic acid | CHEMBL1778342 |
Type | Small organic molecule |
Emp. Form. | C31H35ClN2O7 |
Mol. Mass. | 583.072 |
SMILES | COc1cccc([C@H]2O[C@H](CC(=O)N3CCC(CC(O)=O)CC3)c3noc(C(C)C)c3-c3ccc(Cl)cc23)c1OC |r| |
Structure |
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