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TargetProstaglandin D2 receptor 2
LigandBDBM50344996
Substrate/Competitorn/a
Meas. Tech.ChEMBL_749090 (CHEMBL1780687)
IC50 0.200000±n/a nM
Citation Luker, TBonnert, RSchmidt, JSargent, CPaine, SWThom, SPairaudeau, GPatel, AMohammed, RAkam, EDougall, IDavis, AMAbbott, PBrough, SMillichip, IMcInally, T Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids. Bioorg Med Chem Lett21:3616-21 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM50344996
n/a
NameBDBM50344996
Synonyms:2-(5'-cyano-2'-fluoro-5-(trifluoromethyl)biphenyl-2-yloxy)acetic acid | CHEMBL1778635
TypeSmall organic molecule
Emp. Form.C16H9F4NO3
Mol. Mass.339.2412
SMILESOC(=O)COc1ccc(cc1-c1cc(ccc1F)C#N)C(F)(F)F
Structure
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