| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
|---|
| Ligand | BDBM50345129 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_748738 (CHEMBL1780591) |
|---|
| Ki | 0.81±n/a nM |
|---|
| Citation |  Oost, T; Backfisch, G; Bhowmik, S; van Gaalen, MM; Geneste, H; Hornberger, W; Lubisch, W; Netz, A; Unger, L; Wernet, W Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties. Bioorg Med Chem Lett21:3828-31 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V1b receptor |
|---|
| Name: | Vasopressin V1b receptor |
|---|
| Synonyms: | AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46985.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47901 |
|---|
| Residue: | 424 |
|---|
| Sequence: | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
|
|
|
|---|
| BDBM50345129 |
|---|
| n/a |
|---|
| Name | BDBM50345129 |
|---|
| Synonyms: | (S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-methoxy-4-(pyrrolidin-1-ylmethyl)phenyl)-2-oxoindolin-3-yl)-N,N-dimethylpyrrolidine-2-carboxamide | CHEMBL1779405 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H41ClN4O7S |
|---|
| Mol. Mass. | 697.241 |
|---|
| SMILES | COc1ccc(c(OC)c1)S(=O)(=O)N1C(=O)[C@@](N2CCC[C@H]2C(=O)N(C)C)(c2cc(Cl)ccc12)c1ccc(CN2CCCC2)cc1OC |r| |
|---|
| Structure | 
|
|---|
Search and Browse
