| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
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| Ligand | BDBM50345131 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_748738 (CHEMBL1780591) |
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| Ki | 0.04±n/a nM |
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| Citation |  Oost, T; Backfisch, G; Bhowmik, S; van Gaalen, MM; Geneste, H; Hornberger, W; Lubisch, W; Netz, A; Unger, L; Wernet, W Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties. Bioorg Med Chem Lett21:3828-31 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V1b receptor |
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| Name: | Vasopressin V1b receptor |
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| Synonyms: | AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 46985.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47901 |
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| Residue: | 424 |
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| Sequence: | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
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| BDBM50345131 |
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| n/a |
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| Name | BDBM50345131 |
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| Synonyms: | (S)-1-((R)-5-chloro-3-(2-methoxy-4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(4-methoxyphenylsulfonyl)-2-oxoindolin-3-yl)-N,N-dimethylpyrrolidine-2-carboxamide | CHEMBL1779407 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H42ClN5O6S |
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| Mol. Mass. | 696.256 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)N1C(=O)[C@@](N2CCC[C@H]2C(=O)N(C)C)(c2cc(Cl)ccc12)c1ccc(CN2CCN(C)CC2)cc1OC |r| |
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| Structure | 
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