| Reaction Details |
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 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
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| Ligand | BDBM50346032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_750427 (CHEMBL1785979) |
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| IC50 | 18±n/a nM |
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| Citation |  Balan, G; Bauman, J; Bhattacharya, S; Castrodad, M; Healy, DR; Herr, M; Humphries, P; Jennings, S; Kalgutkar, AS; Kapinos, B; Khot, V; Lazarra, K; Li, M; Li, Y; Neagu, C; Oliver, R; Piotrowski, DW; Price, D; Qi, H; Simmons, HA; Southers, J; Wei, L; Zhang, Y; Paralkar, VM The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorg Med Chem Lett19:3328-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Extracellular calcium-sensing receptor |
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| Name: | Extracellular calcium-sensing receptor |
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| Synonyms: | CASR | CASR_HUMAN | CaR | Calcium sensing receptor | Calcium-sensing receptor (CaSR) | Extracellular calcium-sensing receptor | GPRC2A | PCAR1 | Parathyroid Cell calcium-sensing receptor | Parathyroid cell calcium-sensing receptor 1 | Synonyms=GPRC2A | hCasR |
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| Type: | Protein |
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| Mol. Mass.: | 120663.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41180 |
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| Residue: | 1078 |
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| Sequence: | MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
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| BDBM50346032 |
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| n/a |
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| Name | BDBM50346032 |
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| Synonyms: | 6-[2-((R)-1-{(R)-3-[2-(3-Chloro-4-methyl-phenyl)-1,1-dimethyl-ethylamino]-2-hydroxy-propoxy}-ethyl)-phenyl]-tricyclo[3.2.1.0*2,4*]octane-3-carboxylic acid | CHEMBL1783935 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40ClNO4 |
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| Mol. Mass. | 526.107 |
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| SMILES | C[C@@H](OC[C@H](O)CNC(C)(C)Cc1ccc(C)c(Cl)c1)c1ccccc1C1CC2CC1C1C2C1C(O)=O |r| |
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| Structure | 
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