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TargetHistamine H3 receptor
LigandBDBM50346208
Substrate/Competitorn/a
Meas. Tech.ChEMBL_749354 (CHEMBL1785144)
Ki 0.8±n/a nM
Citation Swanson, DMShah, CRLord, BMorton, KDvorak, LKMazur, CApodaca, RXiao, WBoggs, JDFeinstein, MWilson, SJBarbier, AJBonaventure, PLovenberg, TWCarruthers, NI Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. Eur J Med Chem44:4413-25 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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  Blast E-value cutoff:
BDBM50346208
n/a
NameBDBM50346208
Synonyms:(1-isopropylpiperidin-4-yl)(4-(piperidin-1-ylmethyl)phenyl)methanone | CHEMBL1783889
TypeSmall organic molecule
Emp. Form.C20H31N3O
Mol. Mass.329.4796
SMILESCC(C)N1CCN(CC1)C(=O)c1ccc(CN2CCCCC2)cc1
Structure
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