Reaction Details |
| Report a problem with these data |
Target | Histamine H3 receptor |
---|
Ligand | BDBM50217581 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_749354 (CHEMBL1785144) |
---|
Ki | 2.1±n/a nM |
---|
Citation | Swanson, DM; Shah, CR; Lord, B; Morton, K; Dvorak, LK; Mazur, C; Apodaca, R; Xiao, W; Boggs, JD; Feinstein, M; Wilson, SJ; Barbier, AJ; Bonaventure, P; Lovenberg, TW; Carruthers, NI Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. Eur J Med Chem44:4413-25 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histamine H3 receptor |
---|
Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
BDBM50217581 |
---|
n/a |
---|
Name | BDBM50217581 |
Synonyms: | 4-(4-(1-isopropylpiperidin-4-yloxy)benzyl)morpholine | 4-[4-(1-Isopropyl-piperidin-4-yloxy)-benzyl]-morpholine | CHEMBL194092 |
Type | Small organic molecule |
Emp. Form. | C19H30N2O2 |
Mol. Mass. | 318.4537 |
SMILES | CC(C)N1CCC(CC1)Oc1ccc(CN2CCOCC2)cc1 |
Structure |
|