| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase ICK |
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| Ligand | BDBM50346243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_749968 (CHEMBL1786945) |
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| IC50 | >10000±n/a nM |
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| Citation |  Blackburn, C; Duffey, MO; Gould, AE; Kulkarni, B; Liu, JX; Menon, S; Nagayoshi, M; Vos, TJ; Williams, J Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors. Bioorg Med Chem Lett20:4795-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase ICK |
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| Name: | Serine/threonine-protein kinase ICK |
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| Synonyms: | CILK1 | CILK1_HUMAN | ICK | Intestinal cell kinase | KIAA0936 | LCK2 | Laryngeal cancer kinase 2 | MAK-related kinase | MRK | hICK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71470.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774570 |
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| Residue: | 632 |
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| Sequence: | MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA
NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG
FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP
IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ
CVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDS
EKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDH
PSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWAD
LDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPT
LRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNS
VGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHT
QPRSTPGLIPRPPAAQPVHGRTDWASKYASRR
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| BDBM50346243 |
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| n/a |
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| Name | BDBM50346243 |
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| Synonyms: | CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone | rac-furan-2-yl(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15N3O3 |
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| Mol. Mass. | 333.3407 |
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| SMILES | Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| |
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| Structure | 
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