Reaction Details |
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Target | C-C chemokine receptor type 2 |
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Ligand | BDBM50337619 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_750500 (CHEMBL1786261) |
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IC50 | 3.2±n/a nM |
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Citation | Hughes, RO; Rogier, DJ; Devraj, R; Zheng, C; Cao, G; Feng, H; Xia, M; Anand, R; Xing, L; Glenn, J; Zhang, K; Covington, M; Morton, PA; Hutzler, JM; Davis, JW; Scherle, P; Baribaud, F; Bahinski, A; Mo, ZL; Newton, R; Metcalf, B; Xue, CB Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile. Bioorg Med Chem Lett21:2626-30 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 2 |
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Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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BDBM50337619 |
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n/a |
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Name | BDBM50337619 |
Synonyms: | ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone | ((3S,4S)-N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-3-methoxytetrahydro-2H-pyran-4-amine | CHEMBL1683074 |
Type | Small organic molecule |
Emp. Form. | C25H37F3N4O3 |
Mol. Mass. | 498.5815 |
SMILES | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F |r| |
Structure |
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