| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor p65 |
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| Ligand | BDBM50196926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_749381 (CHEMBL1785171) |
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| IC50 | 75±n/a nM |
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| Citation |  Ren, Y; Matthew, S; Lantvit, DD; Ninh, TN; Chai, H; Fuchs, JR; Soejarto, DD; de Blanco, EJ; Swanson, SM; Kinghorn, AD Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues. J Nat Prod74:1117-25 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor p65 |
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| Name: | Transcription factor p65 |
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| Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60211.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04206 |
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| Residue: | 551 |
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| Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
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| BDBM50196926 |
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| n/a |
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| Name | BDBM50196926 |
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| Synonyms: | CHEMBL438139 | Rocaglamide | US10085988, Compound (-) Roc-A |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31NO7 |
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| Mol. Mass. | 505.5589 |
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| SMILES | COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| |
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| Structure | 
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