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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50346475
Substrate/Competitorn/a
Meas. Tech.ChEMBL_751949
Ki 238±n/a nM
Citation Sunnam SKRack ESchepmann DWünsch B Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore. Eur J Med Chem 46:1972-82 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma-1 receptor
Synonyms:OPRS1 | SIGMAR1 | Sigma 1-type opioid receptor | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:Protein
Mol. Mass.:25307.17
Organism:Cavia porcellus (Guinea pig)
Description:Q60492
Residue:223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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BDBM50346475
n/a
NameBDBM50346475
Synonyms:CHEMBL1782986 | rel-(1RS,2RS,6SR)-7-benzyl-9-(4-methoxybenzyl)-2-(pyrrolidin-1-yl)-7,9-diazabicyclo-[4.2.2]decane | rel-(1RS,2SR,6SR)-7-benzyl-9-(4-methoxybenzyl)-2-(pyrrolidin-1-yl)-7,9-diazabicyclo-[4.2.2]decane
TypeSmall organic molecule
Emp. Form.C27H37N3O
Mol. Mass.419.6022
SMILESCOc1ccc(CN2CC3CCCC(C2CN3Cc2ccccc2)N2CCCC2)cc1 |TLB:24:13:7.8:16.15,THB:17:16:7.8:13.12.11.10|
Structure
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