Reaction Details |
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Target | Lysine-specific histone demethylase 1A |
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Ligand | BDBM50236898 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_753132 (CHEMBL1799132) |
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Ki | 168000±n/a nM |
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Citation | Benelkebir, H; Hodgkinson, C; Duriez, PJ; Hayden, AL; Bulleid, RA; Crabb, SJ; Packham, G; Ganesan, A Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors. Bioorg Med Chem19:3709-16 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific histone demethylase 1A |
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Name: | Lysine-specific histone demethylase 1A |
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
Type: | Enzyme |
Mol. Mass.: | 92901.01 |
Organism: | Homo sapiens (Human) |
Description: | O60341 |
Residue: | 852 |
Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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BDBM50236898 |
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n/a |
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Name | BDBM50236898 |
Synonyms: | (1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL257990 | TRANYLCYPROMINE | Tranylcypromine (TCP) | trans-2-phenylcyclopropanamine | trans-2-phenylcyclopropylamine |
Type | Small organic molecule |
Emp. Form. | C9H11N |
Mol. Mass. | 133.1903 |
SMILES | N[C@H]1C[C@@H]1c1ccccc1 |r| |
Structure |
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