| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50346797 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_753766 (CHEMBL1799647) |
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| IC50 | 13000±n/a nM |
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| Citation |  Nuti, E; Casalini, F; Santamaria, S; Gabelloni, P; Bendinelli, S; Da Pozzo, E; Costa, B; Marinelli, L; La Pietra, V; Novellino, E; Margarida Bernardo, M; Fridman, R; Da Settimo, F; Martini, C; Rossello, A Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem46:2617-29 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50346797 |
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| n/a |
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| Name | BDBM50346797 |
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| Synonyms: | CHEMBL1795351 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N2O4S2 |
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| Mol. Mass. | 392.492 |
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| SMILES | CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)NCC(=O)NO |
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| Structure | 
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