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TargetMatrix metalloproteinase-25
LigandBDBM8465
Substrate/Competitorn/a
Meas. Tech.ChEMBL_753772
IC50 1.5±n/a nM
Citation Nuti ECasalini FSantamaria SGabelloni PBendinelli SDa Pozzo ECosta BMarinelli LLa Pietra VNovellino EMargarida Bernardo MFridman RDa Settimo FMartini CRossello A Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem 46:2617-29 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix metalloproteinase-25
Name:Matrix metalloproteinase-25
Synonyms:Leukolysin | MMP-25 | MT-MMP 6 | MT6-MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase | Membrane-type-6 matrix metalloproteinase (MT6-MMP)
Type:Protein
Mol. Mass.:62564.84
Organism:Homo sapiens (Human)
Description:Q9NPA2
Residue:562
Sequence:
MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD
AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL
TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ
DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG
LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ
PPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFW
EGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVF
SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG
AHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAA
GRWPAPIPLLLLPLLVGGVASR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM8465
n/a
NameBDBM8465
Synonyms:(2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylmethyl)sulfonamido]-3-methylbutanamide | BMCL16311 Compound 1a | CGS 27023 | CGS 27023A | CHEMBL514138 | hydroxamate analogue 1
TypeSmall organic molecule
Emp. Form.C18H23N3O5S
Mol. Mass.393.457
SMILESCOc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: