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TargetAldo-keto reductase family 1 member B1 [K65Q]
LigandBDBM50049730
Substrate/Competitorn/a
Meas. Tech.ChEMBL_753266 (CHEMBL1799477)
IC50 170±n/a nM
Citation Ottanà, RMaccari, RGiglio, MDel Corso, ACappiello, MMura, UCosconati, SMarinelli, LNovellino, ESartini, SLa Motta, CDa Settimo, F Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications. Eur J Med Chem46:2797-806 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member B1 [K65Q]
Name:Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:Protein
Mol. Mass.:35916.27
Organism:Bos taurus (Cattle)
Description:P16116[K65Q]
Residue:315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50049730
n/a
NameBDBM50049730
Synonyms:2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | CHEMBL56337 | Epalrestat | {5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid
TypeSmall organic molecule
Emp. Form.C15H13NO3S2
Mol. Mass.319.399
SMILESC\C(\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1
Structure
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