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TargetHistone Lysine Demethylase
LigandBDBM50418773
Substrate/Competitorn/a
Meas. Tech.ChEMBL_754088
Ki 1980±n/a nM
Citation Lohse BKristensen JLKristensen LHAgger KHelin KGajhede MClausen RP Inhibitors of histone demethylases. Bioorg Med Chem 19:3625-36 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone Lysine Demethylase
Name:Histone Lysine Demethylase
Synonyms:2-OG-Dependent Histone Demethylase JMJD2E | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E)
Type:Enzyme
Mol. Mass.:56815.71
Organism:Homo sapiens (Human)
Description:B2RXH2
Residue:506
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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  Blast E-value cutoff:
BDBM50418773
n/a
NameBDBM50418773
Synonyms:CARBIDOPA
TypeSmall organic molecule
Emp. Form.C10H14N2O4
Mol. Mass.226.2292
SMILESC[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O |r|
Structure
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