| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50346918 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_752896 (CHEMBL1798630) |
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| IC50 | >10000±n/a nM |
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| Citation |  Devadas, B; Selness, SR; Xing, L; Madsen, HM; Marrufo, LD; Shieh, H; Messing, DM; Yang, JZ; Morgan, HM; Anderson, GD; Webb, EG; Zhang, J; Devraj, RV; Monahan, JB Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors. Bioorg Med Chem Lett21:3856-60 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 38936.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48729 |
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| Residue: | 337 |
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| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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| BDBM50346918 |
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| n/a |
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| Name | BDBM50346918 |
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| Synonyms: | CHEMBL1738710 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClF2N3O4 |
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| Mol. Mass. | 449.835 |
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| SMILES | Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO |
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| Structure | 
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