Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRenin
LigandBDBM50347006
Substrate/Competitorn/a
Meas. Tech.ChEMBL_753402 (CHEMBL1799737)
IC50 20±n/a nM
Citation Chen, ACampeau, LCCauchon, EChefson, ADucharme, YDubé, DFalgueyret, JPFournier, PAGagné, SGrimm, EHan, YHoule, RHuang, JQLacombe, PLaliberté, SLévesque, JFLiu, SMacDonald, DMackay, BMcKay, DPercival, MDRegan, CRegan, HSt-Jacques, RToulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines. Bioorg Med Chem Lett21:3970-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50347006
n/a
NameBDBM50347006
Synonyms:CHEMBL1795908
TypeSmall organic molecule
Emp. Form.C22H25Cl2N3O2
Mol. Mass.434.359
SMILESCn1ccc(cc1=O)[C@H]1CCNC[C@@H]1C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: