Reaction Details |
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Target | Renin |
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Ligand | BDBM50340407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_753403 (CHEMBL1799738) |
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IC50 | 5±n/a nM |
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Citation | Chen, A; Campeau, LC; Cauchon, E; Chefson, A; Ducharme, Y; Dubé, D; Falgueyret, JP; Fournier, PA; Gagné, S; Grimm, E; Han, Y; Houle, R; Huang, JQ; Lacombe, P; Laliberté, S; Lévesque, JF; Liu, S; MacDonald, D; Mackay, B; McKay, D; Percival, MD; Regan, C; Regan, H; St-Jacques, R; Toulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines. Bioorg Med Chem Lett21:3970-5 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50340407 |
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n/a |
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Name | BDBM50340407 |
Synonyms: | (3R,4S)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl)piperidine-3-carboxamide | CHEMBL1761519 |
Type | Small organic molecule |
Emp. Form. | C38H48Cl2N2O6 |
Mol. Mass. | 699.704 |
SMILES | COCCCc1cc(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)cc(OCCOC)c1 |r| |
Structure |
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