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TargetRenin
LigandBDBM50347018
Substrate/Competitorn/a
Meas. Tech.ChEMBL_753403 (CHEMBL1799738)
IC50 0.570000±n/a nM
Citation Chen, ACampeau, LCCauchon, EChefson, ADucharme, YDubé, DFalgueyret, JPFournier, PAGagné, SGrimm, EHan, YHoule, RHuang, JQLacombe, PLaliberté, SLévesque, JFLiu, SMacDonald, DMackay, BMcKay, DPercival, MDRegan, CRegan, HSt-Jacques, RToulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines. Bioorg Med Chem Lett21:3970-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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  Blast E-value cutoff:
BDBM50347018
n/a
NameBDBM50347018
Synonyms:CHEMBL1796071
TypeSmall organic molecule
Emp. Form.C28H35BrN4O3
Mol. Mass.555.507
SMILESCOCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccn(C)c(=O)c2)c2c(Br)cccc12 |r|
Structure
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