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TargetMitogen-activated protein kinase 14
LigandBDBM50347101
Substrate/Competitorn/a
Meas. Tech.ChEMBL_752994
IC50 14±n/a nM
Citation Selness SRBoehm TLWalker JKDevadas BDurley RCKurumbail RShieh HXing LHepperle MRucker PVJerome KDBenson AGMarrufo LDMadsen HMHitchcock JOwen TJChristie LPromo MAHickory BSAlvira ENaing WBlevis-Bal RDevraj RVMessing DSchindler JFHirsch JSaabye MBonar SWebb EAnderson GMonahan JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | Cytokine suppressive anti-inflammatory drug-binding protein | MAP Kinase p38 alpha | MAP kinase MXI2 | MAP kinase p38 | MAX-interacting protein 2 | Mitogen-activated protein kinase (MAP) p38 alpha | Mitogen-activated protein kinase (Map p38 alpha) | Mitogen-activated protein kinase 14 (MAP kinase p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14 p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKa) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKÿ±) | Mitogen-activated protein kinase 14 (p38 MAPKa) | Mitogen-activated protein kinase 14 (p38 alpha) | Mitogen-activated protein kinase 14, activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha (p38 MAPKa) | SAPK2A | p38-alpha
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50347101
n/a
NameBDBM50347101
Synonyms:CHEMBL1797204
TypeSmall organic molecule
Emp. Form.C24H22BrF4N3O2
Mol. Mass.540.348
SMILESCN1CCN(CC1)c1cc(F)c(c(F)c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(9.91,-37.66,;8.58,-36.88,;7.24,-37.65,;5.91,-36.88,;5.92,-35.34,;7.25,-34.56,;8.58,-35.34,;4.59,-34.57,;4.59,-33.02,;3.25,-32.26,;3.25,-30.72,;1.93,-33.03,;1.92,-34.57,;.59,-35.33,;3.25,-35.34,;.6,-32.25,;.6,-30.71,;1.93,-29.95,;-.73,-29.94,;-2.06,-30.71,;-3.4,-29.95,;-4.73,-30.72,;-6.06,-29.96,;-7.38,-30.73,;-8.72,-29.97,;-8.73,-28.43,;-10.07,-27.66,;-7.4,-27.65,;-6.06,-28.42,;-4.73,-27.65,;-2.06,-32.25,;-3.39,-33.03,;-.73,-33.02,;-.73,-34.56,)|
Structure
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