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TargetMitogen-activated protein kinase 14
LigandBDBM50347104
Substrate/Competitorn/a
Meas. Tech.ChEMBL_752994
IC50 15±n/a nM
Citation Selness SRBoehm TLWalker JKDevadas BDurley RCKurumbail RShieh HXing LHepperle MRucker PVJerome KDBenson AGMarrufo LDMadsen HMHitchcock JOwen TJChristie LPromo MAHickory BSAlvira ENaing WBlevis-Bal RDevraj RVMessing DSchindler JFHirsch JSaabye MBonar SWebb EAnderson GMonahan JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | Cytokine suppressive anti-inflammatory drug-binding protein | MAP Kinase p38 alpha | MAP kinase MXI2 | MAP kinase p38 | MAX-interacting protein 2 | Mitogen-activated protein kinase (MAP) p38 alpha | Mitogen-activated protein kinase (Map p38 alpha) | Mitogen-activated protein kinase 14 (MAP kinase p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14 p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKa) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKÿ±) | Mitogen-activated protein kinase 14 (p38 MAPKa) | Mitogen-activated protein kinase 14 (p38 alpha) | Mitogen-activated protein kinase 14, activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha (p38 MAPKa) | SAPK2A | p38-alpha
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50347104
n/a
NameBDBM50347104
Synonyms:CHEMBL1797207
TypeSmall organic molecule
Emp. Form.C19H12BrF4NO3
Mol. Mass.458.201
SMILESCc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(O)cc1F |(26.27,-43.79,;24.93,-44.55,;23.6,-43.77,;22.28,-44.55,;20.94,-43.79,;19.61,-44.56,;18.27,-43.79,;16.95,-44.57,;15.62,-43.81,;15.61,-42.26,;14.27,-41.5,;16.94,-41.49,;18.28,-42.25,;19.61,-41.48,;22.28,-46.09,;20.94,-46.86,;23.6,-46.85,;23.6,-48.39,;24.93,-46.09,;26.27,-46.86,;27.59,-46.09,;27.59,-44.55,;28.92,-46.86,;28.93,-48.41,;30.26,-49.18,;27.59,-49.17,;26.26,-48.4,;24.92,-49.17,)|
Structure
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