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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50347109 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_752994 (CHEMBL1798818) | ||
| IC50 | 6±n/a nM | ||
| Citation |  Selness, SR; Boehm, TL; Walker, JK; Devadas, B; Durley, RC; Kurumbail, R; Shieh, H; Xing, L; Hepperle, M; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Devraj, RV; Messing, D; Schindler, JF; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett21:4059-65 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50347109 | |||
| n/a | |||
| Name | BDBM50347109 | ||
| Synonyms: | CHEMBL1797212 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17BrF4N2O2 | ||
| Mol. Mass. | 485.269 | ||
| SMILES | CN(C)Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cccc1F |(3.68,-20.77,;2.34,-21.54,;1.01,-20.77,;2.34,-23.08,;1,-23.85,;-.33,-23.07,;-1.66,-23.85,;-2.99,-23.08,;-4.32,-23.85,;-5.66,-23.09,;-6.98,-23.87,;-8.32,-23.11,;-8.32,-21.56,;-9.66,-20.79,;-6.99,-20.78,;-5.66,-21.55,;-4.32,-20.78,;-1.66,-25.39,;-2.99,-26.16,;-.33,-26.15,;-.33,-27.69,;1,-25.39,;2.33,-26.16,;3.66,-25.39,;3.65,-23.85,;4.99,-26.15,;4.99,-27.7,;3.66,-28.47,;2.33,-27.7,;.99,-28.46,)| | ||
| Structure | 
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