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TargetMitogen-activated protein kinase 14
LigandBDBM50347111
Substrate/Competitorn/a
Meas. Tech.ChEMBL_752994
IC50 9±n/a nM
Citation Selness SRBoehm TLWalker JKDevadas BDurley RCKurumbail RShieh HXing LHepperle MRucker PVJerome KDBenson AGMarrufo LDMadsen HMHitchcock JOwen TJChristie LPromo MAHickory BSAlvira ENaing WBlevis-Bal RDevraj RVMessing DSchindler JFHirsch JSaabye MBonar SWebb EAnderson GMonahan JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | Cytokine suppressive anti-inflammatory drug-binding protein | MAP Kinase p38 alpha | MAP kinase MXI2 | MAP kinase p38 | MAX-interacting protein 2 | Mitogen-activated protein kinase (MAP) p38 alpha | Mitogen-activated protein kinase (Map p38 alpha) | Mitogen-activated protein kinase 14 (MAP kinase p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14 p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKa) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKÿ±) | Mitogen-activated protein kinase 14 (p38 MAPKa) | Mitogen-activated protein kinase 14 (p38 alpha) | Mitogen-activated protein kinase 14, activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha (p38 MAPKa) | SAPK2A | p38-alpha
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50347111
n/a
NameBDBM50347111
Synonyms:CHEMBL1797214
TypeSmall organic molecule
Emp. Form.C23H19BrF4N2O3
Mol. Mass.527.306
SMILESFc1ccc(COc2cc(CN3CCOCC3)n(-c3c(F)cccc3F)c(=O)c2Br)c(F)c1 |(-9.72,-33.39,;-8.38,-34.16,;-8.37,-35.71,;-7.03,-36.47,;-5.71,-35.69,;-4.38,-36.45,;-3.05,-35.68,;-1.71,-36.45,;-.38,-35.67,;.95,-36.45,;2.28,-35.68,;2.29,-34.14,;3.62,-33.38,;3.63,-31.85,;2.3,-31.07,;.96,-31.83,;.95,-33.37,;.95,-37.99,;2.28,-38.76,;3.6,-37.99,;3.6,-36.45,;4.94,-38.75,;4.94,-40.3,;3.6,-41.07,;2.27,-40.3,;.94,-41.06,;-.38,-38.75,;-.38,-40.29,;-1.71,-37.99,;-3.04,-38.76,;-5.71,-34.15,;-4.38,-33.38,;-7.05,-33.38,)|
Structure
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