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TargetMitogen-activated protein kinase 14
LigandBDBM50347126
Substrate/Competitorn/a
Meas. Tech.ChEMBL_752994
IC50 4±n/a nM
Citation Selness SRBoehm TLWalker JKDevadas BDurley RCKurumbail RShieh HXing LHepperle MRucker PVJerome KDBenson AGMarrufo LDMadsen HMHitchcock JOwen TJChristie LPromo MAHickory BSAlvira ENaing WBlevis-Bal RDevraj RVMessing DSchindler JFHirsch JSaabye MBonar SWebb EAnderson GMonahan JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | Cytokine suppressive anti-inflammatory drug-binding protein | MAP Kinase p38 alpha | MAP kinase MXI2 | MAP kinase p38 | MAX-interacting protein 2 | Mitogen-activated protein kinase (MAP) p38 alpha | Mitogen-activated protein kinase (Map p38 alpha) | Mitogen-activated protein kinase 14 (MAP kinase p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14 p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKa) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKÿ±) | Mitogen-activated protein kinase 14 (p38 MAPKa) | Mitogen-activated protein kinase 14 (p38 alpha) | Mitogen-activated protein kinase 14, activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha (p38 MAPKa) | SAPK2A | p38-alpha
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50347126
n/a
NameBDBM50347126
Synonyms:CHEMBL1797124
TypeSmall organic molecule
Emp. Form.C19H12ClF4NO2
Mol. Mass.397.751
SMILESCc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F |(27.98,3.45,;26.64,2.68,;25.32,3.46,;23.99,2.68,;22.65,3.45,;21.32,2.68,;19.98,3.44,;18.66,2.66,;17.33,3.42,;17.32,4.97,;15.98,5.74,;18.65,5.75,;19.99,4.98,;21.32,5.75,;23.99,1.14,;22.65,.37,;25.32,.38,;25.32,-1.16,;26.64,1.14,;27.98,.37,;29.3,1.14,;29.3,2.68,;30.63,.38,;30.64,-1.17,;29.3,-1.94,;27.97,-1.17,;26.63,-1.93,)|
Structure
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