| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Ligand | BDBM50347339 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_755118 (CHEMBL1805698) |
|---|
| IC50 | 0.55±n/a nM |
|---|
| Citation |  Gallant, M; Aspiotis, R; Day, S; Dias, R; Dubé, D; Dubé, L; Friesen, RW; Girard, M; Guay, D; Hamel, P; Huang, Z; Lacombe, P; Laliberté, S; Lévesque, JF; Liu, S; Macdonald, D; Mancini, J; Nicholson, DW; Styhler, A; Townson, K; Waters, K; Young, RN; Girard, Y Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. Bioorg Med Chem Lett20:6387-93 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83318.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07343 |
|---|
| Residue: | 736 |
|---|
| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
|---|
| BDBM50347339 |
|---|
| n/a |
|---|
| Name | BDBM50347339 |
|---|
| Synonyms: | CHEMBL1801151 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H23N7O2 |
|---|
| Mol. Mass. | 489.5279 |
|---|
| SMILES | O=C(NC1CC1)c1cn(-c2cccc(c2)-c2ccc(cc2)C2CC2c2nnn[nH]2)c2ncccc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
