| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 4 |
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| Ligand | BDBM50347490 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_754437 (CHEMBL1806025) |
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| IC50 | 0.8±n/a nM |
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| Citation |  Zhu, A; Zhan, W; Liang, Z; Yoon, Y; Yang, H; Grossniklaus, HE; Xu, J; Rojas, M; Lockwood, M; Snyder, JP; Liotta, DC; Shim, H Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. J Med Chem53:8556-68 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 4 |
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| Name: | C-X-C chemokine receptor type 4 |
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| Synonyms: | C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 39754.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61073 |
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| Residue: | 352 |
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| Sequence: | MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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| BDBM50347490 |
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| n/a |
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| Name | BDBM50347490 |
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| Synonyms: | CHEMBL1802333 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26ClFN8O |
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| Mol. Mass. | 472.946 |
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| SMILES | Fc1cnc(Cl)nc1NCc1ccc(CNc2ccnc(NCCN3CCOCC3)n2)cc1 |
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| Structure | 
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