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TargetTranscription factor p65
LigandBDBM50347545
Substrate/Competitorn/a
Meas. Tech.ChEMBL_756042 (CHEMBL1804152)
IC50>50000±n/a nM
Citation Ayers, SGraf, TNAdcock, AFKroll, DJMatthew, SCarcache de Blanco, EJShen, QSwanson, SMWani, MCPearce, CJOberlies, NH Resorcylic acid lactones with cytotoxic and NF-¿B inhibitory activities and their structure-activity relationships. J Nat Prod74:1126-31 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcription factor p65
Name:Transcription factor p65
Synonyms:NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:Enzyme
Mol. Mass.:60211.92
Organism:Homo sapiens (Human)
Description:Q04206
Residue:551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50347545
n/a
NameBDBM50347545
Synonyms:CHEMBL1801949
TypeSmall organic molecule
Emp. Form.C19H24O7
Mol. Mass.364.3897
SMILESCOc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)[C@H](O)\C=C\C[C@H](C)OC2=O |r,t:10,19|
Structure
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