| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SETD7 |
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| Ligand | BDBM50347712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_756196 (CHEMBL1804746) |
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| IC50 | 149000±n/a nM |
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| Citation |  Cheng, D; Valente, S; Castellano, S; Sbardella, G; Di Santo, R; Costi, R; Bedford, MT; Mai, A Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem54:4928-32 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SETD7 |
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| Name: | Histone-lysine N-methyltransferase SETD7 |
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| Synonyms: | Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40691.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8WTS6 |
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| Residue: | 366 |
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| Sequence: | MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
QATQQK
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| BDBM50347712 |
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| n/a |
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| Name | BDBM50347712 |
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| Synonyms: | CHEMBL1802467 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21Br2NO4 |
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| Mol. Mass. | 583.268 |
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| SMILES | Oc1ccc(C=C2CN(CC(=O)c3ccccc3)CC(=Cc3ccc(O)c(Br)c3)C2=O)cc1Br |w:20.21,5.4| |
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| Structure | 
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