| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interferon-induced, double-stranded RNA-activated protein kinase |
|---|
| Ligand | BDBM6860 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_756675 (CHEMBL1805140) |
|---|
| IC50 | 6000±n/a nM |
|---|
| Citation |  Bryk, R; Wu, K; Raimundo, BC; Boardman, PE; Chao, P; Conn, GL; Anderson, E; Cole, JL; Duffy, NP; Nathan, C; Griffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett21:4108-14 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interferon-induced, double-stranded RNA-activated protein kinase |
|---|
| Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
|---|
| Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62104.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1467743 |
|---|
| Residue: | 551 |
|---|
| Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
|
|
|
|---|
| BDBM6860 |
|---|
| n/a |
|---|
| Name | BDBM6860 |
|---|
| Synonyms: | 6-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione | Indolocarbazole deriv. 4(d) |
|---|
| Type | Small Organic Molecule |
|---|
| Emp. Form. | C20H10BrN3O2 |
|---|
| Mol. Mass. | 404.216 |
|---|
| SMILES | Brc1ccc2c(c1)[nH]c1c3[nH]c4ccccc4c3c3C(=O)NC(=O)c3c21 |
|---|
| Structure | 
|
|---|
Search and Browse
