Reaction Details |
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Target | Interferon-induced, double-stranded RNA-activated protein kinase |
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Ligand | BDBM50347923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_756675 (CHEMBL1805140) |
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IC50 | 3500±n/a nM |
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Citation | Bryk, R; Wu, K; Raimundo, BC; Boardman, PE; Chao, P; Conn, GL; Anderson, E; Cole, JL; Duffy, NP; Nathan, C; Griffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett21:4108-14 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interferon-induced, double-stranded RNA-activated protein kinase |
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Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
Type: | PROTEIN |
Mol. Mass.: | 62104.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1467743 |
Residue: | 551 |
Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
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BDBM50347923 |
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n/a |
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Name | BDBM50347923 |
Synonyms: | CHEMBL1802729 |
Type | Small organic molecule |
Emp. Form. | C19H16N4O3 |
Mol. Mass. | 348.3553 |
SMILES | [O-][N+](=O)c1ccc2NC3C(CC(=O)Nc4ccc(CCC#N)cc34)c2c1 |
Structure |
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