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TargetInterferon-induced, double-stranded RNA-activated protein kinase
LigandBDBM50347923
Substrate/Competitorn/a
Meas. Tech.ChEMBL_756675 (CHEMBL1805140)
IC50 3500±n/a nM
Citation Bryk, RWu, KRaimundo, BCBoardman, PEChao, PConn, GLAnderson, ECole, JLDuffy, NPNathan, CGriffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett21:4108-14 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interferon-induced, double-stranded RNA-activated protein kinase
Name:Interferon-induced, double-stranded RNA-activated protein kinase
Synonyms:E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase
Type:PROTEIN
Mol. Mass.:62104.61
Organism:Homo sapiens (Human)
Description:ChEMBL_1467743
Residue:551
Sequence:
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
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BDBM50347923
n/a
NameBDBM50347923
Synonyms:CHEMBL1802729
TypeSmall organic molecule
Emp. Form.C19H16N4O3
Mol. Mass.348.3553
SMILES[O-][N+](=O)c1ccc2NC3C(CC(=O)Nc4ccc(CCC#N)cc34)c2c1
Structure
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