| Reaction Details |
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 | Report a problem with these data |
| Target | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Ligand | BDBM6878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_756675 (CHEMBL1805140) |
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| IC50 | 1600±n/a nM |
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| Citation |  Bryk, R; Wu, K; Raimundo, BC; Boardman, PE; Chao, P; Conn, GL; Anderson, E; Cole, JL; Duffy, NP; Nathan, C; Griffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett21:4108-14 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interferon-induced, double-stranded RNA-activated protein kinase |
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| Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62104.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467743 |
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| Residue: | 551 |
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| Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
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| BDBM6878 |
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| n/a |
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| Name | BDBM6878 |
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| Synonyms: | 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n | 5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13F2N7O2S2 |
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| Mol. Mass. | 425.436 |
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| SMILES | Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F |
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| Structure | 
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