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TargetCytochrome P450 2D6 (2D6)
LigandBDBM50347939
Substrate/Competitorn/a
Meas. Tech.ChEMBL_755920
IC50>8900±n/a nM
Citation Wu TNagle AKuhen KGagaring KBorboa RFrancek CChen ZPlouffe DGoh ALakshminarayana SBWu JAng HQZeng PKang MLTan WTan MYe NLin XCaldwell CEk JSkolnik SLiu FWang JChang JLi CHollenbeck TTuntland TIsbell JFischli CBrun RRottmann MDartois VKeller TDiagana TWinzeler EGlynne RTully DCChatterjee AK Imidazolopiperazines: hit to lead optimization of new antimalarial agents. J Med Chem 54:5116-30 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50347939
n/a
NameBDBM50347939
Synonyms:CHEMBL1800137
TypeSmall organic molecule
Emp. Form.C22H23F2N5O
Mol. Mass.411.4477
SMILESCC(C)(N)C(=O)N1CCn2c(C1)nc(c2Nc1ccc(F)cc1)-c1ccc(F)cc1
Structure
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