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TargetCytochrome P450 1A
LigandBDBM50347939
Substrate/Competitorn/a
Meas. Tech.ChEMBL_755917
IC50>8900±n/a nM
Citation Wu TNagle AKuhen KGagaring KBorboa RFrancek CChen ZPlouffe DGoh ALakshminarayana SBWu JAng HQZeng PKang MLTan WTan MYe NLin XCaldwell CEk JSkolnik SLiu FWang JChang JLi CHollenbeck TTuntland TIsbell JFischli CBrun RRottmann MDartois VKeller TDiagana TWinzeler EGlynne RTully DCChatterjee AK Imidazolopiperazines: hit to lead optimization of new antimalarial agents. J Med Chem 54:5116-30 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 1A
Name:Cytochrome P450 1A
Synonyms:CYPIA2 | Cytochrome P450 1A2 | Cytochrome P450 1A2 (CYP1A2)
Type:Enzyme
Mol. Mass.:58310.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:515
Sequence:
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARRFSIN
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  Blast E-value cutoff:
BDBM50347939
n/a
NameBDBM50347939
Synonyms:CHEMBL1800137
TypeSmall organic molecule
Emp. Form.C22H23F2N5O
Mol. Mass.411.4477
SMILESCC(C)(N)C(=O)N1CCn2c(C1)nc(c2Nc1ccc(F)cc1)-c1ccc(F)cc1
Structure
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