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TargetGonadotropin-releasing hormone receptor
LigandBDBM50347991
Substrate/Competitorn/a
Meas. Tech.ChEMBL_756122 (CHEMBL1804378)
IC50 0.37±n/a nM
Citation Miwa, KHitaka, TImada, TSasaki, SYoshimatsu, MKusaka, MTanaka, ANakata, DFuruya, SEndo, SHamamura, KKitazaki, T Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem54:4998-5012 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin-releasing hormone receptor
Name:Gonadotropin-releasing hormone receptor
Synonyms:GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:Enzyme
Mol. Mass.:37749.45
Organism:Homo sapiens (Human)
Description:P30968
Residue:328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50347991
n/a
NameBDBM50347991
Synonyms:CHEMBL1800670
TypeSmall organic molecule
Emp. Form.C30H35F2N5O6S
Mol. Mass.631.691
SMILESCCOCCn1c(=O)n(Cc2c(F)cccc2F)c2sc(c(CN(C)CCOC)c2c1=O)-c1ccc(NC(=O)NOC)cc1
Structure
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