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TargetProtein-S-isoprenylcysteine O-methyltransferase
LigandBDBM50348049
Substrate/Competitorn/a
Meas. Tech.ChEMBL_757250 (CHEMBL1803626)
IC50 31±n/a nM
Citation Judd, WRSlattum, PMHoang, KCBhoite, LValppu, LAlberts, GBrown, BRoth, BOstanin, KHuang, LWettstein, DRichards, BWillardsen, JA Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem54:5031-47 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-S-isoprenylcysteine O-methyltransferase
Name:Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:PROTEIN
Mol. Mass.:31943.26
Organism:Homo sapiens (Human)
Description:ChEMBL_956034
Residue:284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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BDBM50348049
n/a
NameBDBM50348049
Synonyms:CHEMBL1800496
TypeSmall organic molecule
Emp. Form.C22H27F2NO2
Mol. Mass.375.4521
SMILESCOc1c(F)cc(NCCC2(CCOC(C)(C)C2)c2ccccc2)cc1F
Structure
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