| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50348376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_757640 (CHEMBL1804897) |
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| IC50 | >100000±n/a nM |
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| Citation |  Kemp, MM; Wang, Q; Fuller, JH; West, N; Martinez, NM; Morse, EM; Weïwer, M; Schreiber, SL; Bradner, JE; Koehler, AN A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. Bioorg Med Chem Lett21:4164-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50348376 |
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| n/a |
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| Name | BDBM50348376 |
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| Synonyms: | CHEMBL1800375 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11ClN2O2S |
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| Mol. Mass. | 294.757 |
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| SMILES | Cc1cc(=O)[nH]c(SCC(=O)c2ccc(Cl)cc2)n1 |
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| Structure | 
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