| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
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| Ligand | BDBM50348459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_754900 (CHEMBL1805884) |
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| IC50 | <1000±n/a nM |
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| Citation |  Myatt, JW; Healy, MP; Bravi, GS; Billinton, A; Johnson, CN; Matthews, KL; Jandu, KS; Meng, W; Hersey, A; Livermore, DG; Douault, CB; Witherington, J; Bit, RA; Rowedder, JE; Brown, JD; Clayton, NM Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain. Bioorg Med Chem Lett20:4683-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel subunit alpha-2/delta-2 |
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| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
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| Synonyms: | CA2D2_HUMAN | CACNA2D2 | KIAA0558 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 129803.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_754900 |
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| Residue: | 1150 |
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| Sequence: | MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGAS
AYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVA
GDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVER
GSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRR
QDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSG
SVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAV
QGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRT
VRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEA
KQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPN
YTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGN
KGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQV
KLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSK
QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTE
NPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPA
VVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLV
LSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVF
VPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQY
YFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGP
EQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQP
QVLVHASRRL
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| BDBM50348459 |
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| n/a |
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| Name | BDBM50348459 |
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| Synonyms: | CHEMBL1801209 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N5O |
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| Mol. Mass. | 351.4454 |
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| SMILES | CCOc1ccc(cc1)-n1nc2c(nnc(C)c2c1C)N1CCCCC1 |
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| Structure | 
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