| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
|---|
| Ligand | BDBM50348466 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_754894 (CHEMBL1805878) |
|---|
| IC50 | 5±n/a nM |
|---|
| Citation |  Myatt, JW; Healy, MP; Bravi, GS; Billinton, A; Johnson, CN; Matthews, KL; Jandu, KS; Meng, W; Hersey, A; Livermore, DG; Douault, CB; Witherington, J; Bit, RA; Rowedder, JE; Brown, JD; Clayton, NM Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain. Bioorg Med Chem Lett20:4683-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 |
|---|
| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
|---|
| Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2-1 | Voltage-dependent calcium channel subunit delta-1 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 1 | Voltage-gated calcium channel subunit alpha-2/delta-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 124544.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54289 |
|---|
| Residue: | 1103 |
|---|
| Sequence: | MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL
|
|
|
|---|
| BDBM50348466 |
|---|
| n/a |
|---|
| Name | BDBM50348466 |
|---|
| Synonyms: | CHEMBL1801178 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N5O2 |
|---|
| Mol. Mass. | 353.4182 |
|---|
| SMILES | CCOc1ccc(cc1)-n1nc2c(nnc(C)c2c1C)N1CC[C@@H](O)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
