| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
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| Ligand | BDBM50348546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_754999 (CHEMBL1805901) |
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| IC50 | 5±n/a nM |
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| Citation |  Revesz, L; Schlapbach, A; Aichholz, R; Feifel, R; Hawtin, S; Heng, R; Hiestand, P; Jahnke, W; Koch, G; Kroemer, M; Möbitz, H; Scheufler, C; Velcicky, J; Huppertz, C In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I. Bioorg Med Chem Lett20:4715-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 2 |
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| Name: | MAP kinase-activated protein kinase 2 |
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| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45579.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49137 |
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| Residue: | 400 |
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| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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| BDBM50348546 |
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| n/a |
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| Name | BDBM50348546 |
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| Synonyms: | CHEMBL1801385 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N4O2 |
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| Mol. Mass. | 452.5475 |
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| SMILES | O=C1NCCc2[nH]c3c(ccc4cnc(\C=C\c5cccc(CCN6CCOCC6)c5)cc34)c12 |
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| Structure | 
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