Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMelanocortin receptor 4
LigandBDBM50348568
Substrate/Competitorn/a
Meas. Tech.ChEMBL_755005 (CHEMBL1805907)
IC50 2.6±n/a nM
Citation He, SYe, ZDobbelaar, PHSebhat, IKGuo, LLiu, JJian, TLai, YFranklin, CLBakshi, RKDellureficio, JPHong, QWeinberg, DHMacneil, TTang, RStrack, AMTamvakopoulos, CPeng, QMiller, RRStearns, RAChen, HYChen, ASFong, TMWyvratt, MJNargund, RP Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity. Bioorg Med Chem Lett20:4399-405 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50348568
n/a
NameBDBM50348568
Synonyms:CHEMBL1801126
TypeSmall organic molecule
Emp. Form.C35H46ClF2N3O3
Mol. Mass.630.208
SMILESCc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NCCO |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: