Reaction Details |
| Report a problem with these data |
Target | Matrix metalloproteinase-14 |
---|
Ligand | BDBM50348675 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_754465 (CHEMBL1806090) |
---|
IC50 | 4.5±n/a nM |
---|
Citation | Becker, DP; Barta, TE; Bedell, LJ; Boehm, TL; Bond, BR; Carroll, J; Carron, CP; Decrescenzo, GA; Easton, AM; Freskos, JN; Funckes-Shippy, CL; Heron, M; Hockerman, S; Howard, CP; Kiefer, JR; Li, MH; Mathis, KJ; McDonald, JJ; Mehta, PP; Munie, GE; Sunyer, T; Swearingen, CA; Villamil, CI; Welsch, D; Williams, JM; Yu, Y; Yao, J Orally active MMP-1 sparinga-tetrahydropyranyl anda-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem53:6653-80 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Matrix metalloproteinase-14 |
---|
Name: | Matrix metalloproteinase-14 |
Synonyms: | MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase |
Type: | Protein |
Mol. Mass.: | 65900.19 |
Organism: | Homo sapiens (Human) |
Description: | P50281 |
Residue: | 582 |
Sequence: | MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
|
|
|
BDBM50348675 |
---|
n/a |
---|
Name | BDBM50348675 |
Synonyms: | CHEMBL1801045 |
Type | Small organic molecule |
Emp. Form. | C18H18ClNO6S |
Mol. Mass. | 411.857 |
SMILES | ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 |
Structure |
|